Table 2B.
GBE-HCC vs CNTL: Top 20 genes with concordance of hypermethylated promoter regions and downregulation of gene expression. Genes with at least 4 probes overlapping +/− 2Kb of TSS and P-value <=0.005 ordered according to gene expression fold change.
| Gene Symbols | Gene Name | RefSeq Gene | Methylation Foldchange | Methylation P-value | Expression Foldchange | Expression P-value |
|---|---|---|---|---|---|---|
| Mup9 | Major urinary protein 9 | NM_001281979 | 1.2411 | 0.0308 | −20.2562 | 0.0008 |
| Mup10 | Major urinary protein 10 | NM_001122647 | 1.3041 | 0.0168 | −15.7589 | 0.0021 |
| Mup12 | Major urinary protein 12 | NM_001199995 | 1.5084 | 0.0012 | −15.5871 | 0.0049 |
| Cyp2f2 | Cytochrome P450, family 2, subfamily f, polypeptide 2 | NM_007817 | 1.2696 | 0.0025 | −12.7422 | 0.0138 |
| C8a | Complement C8 alpha chain | NM_001290645 /// NM_001316667 /// NM_146148 | 1.2965 | 0.0004 | −7.8226 | 0.0001 |
| Mup13 | Major urinary protein 13 | NM_001134674 | 1.2892 | 0.0259 | −7.4205 | 0.0376 |
| Mup19 | Major urinary protein 19 | NM_001135127 | 1.2331 | 0.0037 | −7.4205 | 0.0376 |
| Mup7 | Major urinary protein 7 | NM_001134675 | 1.3431 | 0.0019 | −7.4205 | 0.0376 |
| Mup8 | Major urinary protein 8 | NM_001134676 | 1.3356 | 0.0159 | −7.4205 | 0.0376 |
| Perp | P53 Apoptosis Effector Related to PMP22 | NM_022032 | 1.2024 | 0.0034 | −5.7755 | 0.0003 |
| Cyp8b1 | Cytochrome P450, family 8, subfamily b, polypeptide 1 | NM_010012 | 1.2519 | 0.0002 | −4.8848 | 0.0009 |
| Asic5 | Acid-sensing ion channel family member 5 | NM_021370 | 1.2243 | 0.0007 | −4.1873 | 0.0005 |
| Slc3a1 | Solute carrier family 3 member 1 | NM_009205 | 1.2355 | 0.0011 | −3.6061 | 0.0089 |
| S1pr5 | Sphingosine-1-phosphate receptor 5 | NM_053190 | 1.2277 | 0.0049 | −3.5562 | 0.0000 |
| Pigr | Polymeric immunoglobulin receptor | NM_011082 | 1.5604 | 0.0001 | −3.5354 | 0.0317 |
| C8b | Complement C8 beta chain | NM_001316671 /// NM_133882 | 1.2578 | 0.0006 | −3.5304 | 0.0005 |
| Cyp2u1 | Cytochrome P450, family 2, subfamily u, polypeptide 1 | NM_027816 | 1.2508 | 0.0047 | −3.3892 | 0.0001 |
| Hsd17b13 | Hydroxysteroid 17-beta dehydrogenase 13 | NM_001163486 /// NM_198030 | 1.2361 | 0.0012 | −3.2950 | 0.0105 |
| Lrtm1 | Leucine-rich repeats and transmembrane domains 1 | NM_176920 | 1.2940 | 0.0010 | −3.2036 | 0.0000 |
| Cyp2c23 | Cytochrome P450, family 2, subfamily c, polypeptide 23 | NM_001001446 /// NM_001167905 | 1.2291 | 0.0007 | −2.8640 | 0.0008 |