Table 2D.
SPNT-HCC vs CNTL: Top 20 genes with concordance of hypermethylated promoter regions and downregulation of gene expression. Genes with at least 4 probes overlapping +/− 2Kb of TSS and P-value <=0.005 ordered according to gene expression fold change.
| Gene Symbols | Gene Name | RefSeq Gene | Methylation Foldchange | Methylation P-value | Expression Foldchange | Expression P-value |
|---|---|---|---|---|---|---|
| Gna14 | G protein subunit alpha 14 | NM_008137 | 1.2931 | 0.0000 | −4.4985 | 0.0000 |
| Mgll | Monoglyceride lipase | NM_001166249 /// NM_011844 | 1.2345 | 0.0000 | −2.5745 | 0.0001 |
| Aldh5a1 | Aldehyde dehydrogenase 5 family member A1 | NM_172532 | 1.2043 | 0.0000 | −2.5135 | 0.0000 |
| Id3 | Inhibitor of DNA binding 3 | NM_008321 | 1.7932 | 0.0000 | −3.4771 | 0.0060 |
| Csrp3 | Cysteine and glycine-rich protein 3 | NM_013808 | 1.3016 | 0.0000 | −4.9180 | 0.0000 |
| Cyp8b1 | Cytochrome P450, family 8, subfamily b, polypeptide 1 | NM_010012 | 1.2787 | 0.0001 | −39.3978 | 0.0000 |
| Kcnk5 | Potassium channel, subfamily K, member 5 | NM_021542 | 1.2521 | 0.0001 | −2.0600 | 0.0000 |
| Them7 | Thioesterase superfamily member 7 | NM_001159638 /// NM_028747 | 1.3703 | 0.0001 | −2.3785 | 0.0004 |
| Lppos | LIM domain containing preferred translocation partner in lipoma, opposite strand | NR_037954 | 1.2513 | 0.0002 | −2.2850 | 0.0000 |
| Slc46a3 | Solute carrier family 46 member 3 | NM_027872 | 1.2321 | 0.0004 | −2.6685 | 0.0000 |
| Abcc3 | ATP binding cassette subfamily C member 3 | NM_029600 | 1.2294 | 0.0005 | −2.1311 | 0.0126 |
| Tat | Tyrosine aminotransferase | NM_146214 | 1.4520 | 0.0005 | −2.1282 | 0.0033 |
| Asl | Argininosuccinate lyase | NM_133768 | 1.2134 | 0.0005 | −2.5087 | 0.0000 |
| Cyp2c23 | Cytochrome P450, family 2, subfamily c, polypeptide 23 | NM_001001446 /// NM_001167905 | 1.2108 | 0.0007 | −3.9800 | 0.0001 |
| Fam214a | Family with sequence similarity 214, member A | NM_153584 | 1.3726 | 0.0007 | −3.2562 | 0.0000 |
| Prlr | Prolactin receptor | NM_011169 | 1.2647 | 0.0008 | −2.2455 | 0.0042 |
| Pigr | Polymeric immunoglobulin receptor | NM_011082 | 1.3323 | 0.0011 | −6.3871 | 0.0034 |
| Hpgd | Hydroxyprostaglandin dehydrogenase 15 | NM_008278 | 1.2429 | 0.0015 | −2.0069 | 0.0018 |
| Dpys | Dihydropyrimidinase | NM_001164466 /// NM_022722 | 1.2045 | 0.0016 | −2.3561 | 0.0005 |
| Lrtm1 | Leucine-rich repeats and transmembrane domains 1 | NM_176920 | 1.2303 | 0.0023 | −4.8227 | 0.0000 |