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. Author manuscript; available in PMC: 2020 Aug 1.

Published in final edited form as: Arch Toxicol. 2019 Jul 5;93(8):2219–2235. doi: 10.1007/s00204-019-02505-7

Table 3.

Differential methylation and differential gene expression profiles of c-Myc, Spry2 and Dusp5 from array data.

	GBE-HCC vs. CNTL				SPNT-HCC vs. CNTL
Genes	Promoter Methylation		Gene Expression		Promoter Methylation		Gene Expression
Genes	Fold change	p-value	Fold change	p-value	Fold change	p-value	Fold change	p-value
*c-Myc*	−1.04	0.3841	2.22	<0.0001	1.01	0.7517	1.48	0.0051
*Myct1*	−1.32	<0.0001	−1.05	0.7180	−1.23	0.0001	1.01	0.9458
*Spry2*	1.21	<0.0001	1.11	0.5966	−1.02	0.4496	1.70	0.0120
*Dusp5*	1.11	0.0161	1.14	0.0865	−1.07	0.0630	3.48	<0.0001