Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 1;14:8543–8560. doi: 10.2147/IJN.S219820

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Zhong et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Characterization of nanoparticles and the iRGD peptide.

Notes: (A) Nanoparticles exhibited opalescence and Tyndall effect compared to that observed for deionized water. (B) PLGA-PTX exhibited an average particle size of 147.5±9.5 nm with a narrow size distribution (PDI<0.1). (C) Nanoparticles were spherical in shape and possessed smooth surfaces as shown in the transmission electron microscopy image (scale bar = 200 nm). (D) Changes in PLGA-PTX particle size at different storage times in PBS and PVA at 4°C. (E) PLGA-PTX exhibited a sustained release in pH 6.4 and pH 7.4 PBS containing 0.1% Tween-80. (F) The disulfide bond of iRGD was determined in the absence (non-reducing) or presence (reducing) of DTT by mass spectrometry.

Abbreviations: PLGA, poly lactic-co-glycolic acid; PTX, paclitaxel; PLGA-PTX, paclitaxel-loaded PLGA; PDI, polydispersity index; PBS, phosphate buffer saline. DTT, dithiothreitol.