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. Author manuscript; available in PMC: 2020 Apr 24.
Published in final edited form as: J Am Chem Soc. 2019 Apr 15;141(16):6453–6457. doi: 10.1021/jacs.8b13681

Figure 3.

Figure 3.

MDA-MB-231, triple negative breast cancer cells, were incubated with AP-1 or cisplatin for 4h and 8h and the extent of adduct DNA formation was determined by ICP-MS, where the amount of platinum and arsenic were in pmolM/μg DNA (M = Pt or As). Results shown are average of at least five independent experiments. Analysis of one-way-ANOVA using Bonferroni multiple comparison has shown that the difference in the amount of platinum and arsenic in DNA adducts in 8h experiment is highly significant (p ≤ 0.0001).