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Resistant mechanisms of EGFR targeted therapy. The following molecular activities will result in bypassing EGFR blockade: (A) Activation mutations or amplification of EGFR downstream signaling effectors; (B) Overexpression of MET proto-oncogene and expression of EGFR variant III; (C) Hetero-dimerization between EGFR family members; and (D) Activation of TGF-beta IL-6 axis
