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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Mult Scler Relat Disord. 2019 Aug 13;35:276–282. doi: 10.1016/j.msard.2019.08.014

Table 2:

MRI Associations with 25(OH)D3 and Clinical Features

T1 Volume
r* (P value)		 T2 Volume
r* (P value)		 BPF
r (P value)		 WB-MTR
r (P value)		 NABT-MTR
r (P value)		 NAGM-MTR
r (P value)
25(OH)D3 0.03 (0.59) 0.01 ( 0.91) −0.06 (0.31) 0.17 (0.007) 0.12 ( 0.07) 0.15 (0.02)
D-9HPT 0.16 (0.01) 0.15 (0.01) 0.02 (0.77) −0.04 (0.55) −0.02 (0.69) −0.02 (0.74)
T25FW 0.07 (0.27) 0.07 (0.24) 0 (0.99) −0.05 (0.41) −0.04 (0.49) −0.05 (0.42)
LCVA −0.15 (0.01) −0.15 (0.02) 0.15 (0.01) 0.06 (0.37) 0.07 (0.29) 0.06 (0.37)
SDMT −0.31 (<0.001) −0.31 (<0.001) 0.38 (<0.001) 0.20 (0.001) 0.27 (<0.001) 0.19 (0.002)
EDSS 0.20 (0.001) 0.23 (<0.001) −0.21 (<0.001) −0.08 (0.20) −0.09 (0.14) −0.16 (0.01)
*

Spearman correlation coefficient

25[OH]D3, 25-hydroxyvitamin D3; D-9HPT, dominant hand 9-hole peg test; T25FW, timed 25 foot walk; LCVA , 2.5% low contrast visual acuity test; SDMT, Symbol Digit Modality Test; EDSS, Expanded Disability Status Scale; BPF, brain parenchymal fraction; WB-MTR, whole brain magnetization transfer ratio; NABT-MTR, normal appearing brain tissue MTR; NAGM-MTR, normal appearing grey matter MTR