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Adoptive transfer of Tregs protects the reduction of islet size and number in diabetic mice. Diabetic mice were adoptively transferred with Ag-specific Tregs or cell control. Mice were sacrificed, and their pancreases were prepared for HE staining. Islet size and number were reduced markedly in diabetic mice receiving control cells, which were normal in mice receiving Tregs. Islet is indicated by the red arrow. Scale bar: 20 μm
