. 2019 Oct 29;9(10):e028763. doi: 10.1136/bmjopen-2018-028763

Table 1.

Financial implications of switching from MDIs to DPIs

Inhaler type (and most common example)	Number prescribed in 2017	Total cost of this type of inhaler (£)	Cheapest DPI alternative	Cost (£) change with proportional replacement (per 10%)	Cost (£) change with cheapest replacement (per 10%)
SABA (salbutamol MDI)	21 930 625	58 195 683.24	Salbutamol 100 Easyhaler	3 068 201.99	3 042 770.28
LABA (salmeterol 25 MDI)	700 145	25 250 958.95	Formoterol Easyhaler	1 474 723.02	−1 018 957.21
Very low dose ICS (Clenil modulite 50)	887 342	3 814 625.02	Flixotide Accuhaler 50, one inhalation twice a day	875 534.13	875 534.13
Low dose ICS (Clenil modulite 100)	3 874 077	36 581 577.50	Beclometasone Easyhaler 200, one inhalation twice a day	2 461 791.16	−213 579.26
Medium dose ICS (Clenil modulite 200)	1 683 466	34 611 159.90	Beclometasone Easyhaler 200, two inhalations twice a day	3 828 332.15	−628 752.90
High dose ICS (Clenil modulite 250)	287 604	7 923 785.74	Budesonide Easyhaler 400, two inhalations twice a day	1 084 787.73	173 464.97
Low dose ICS+LABA (Seretide 50 Evohaler)	1 181 941	32 582 876.16	Duoresp Spiromax 160/4.5, one inhalation twice a day	749 613.82	121 485.45
Medium dose ICS+LABA (Fostair 100/6 MDI)	9 467 562	373 045 012.90	Relvar Ellipta 92/, one inhalation once a day	3 124 173.89	−4 876 327.15
Medium dose ICS+LABA (Fostair 100/6 MDI)	9 467 562	373 045 012.90	OR Fostair 100/6 Nexthaler two inhalations twice a day	3 124 173.89	OR −1 123 070.10
High dose ICS+LABA (Seretide 250 Evohaler)	3 425 542	184 212 379.80	Fostair 200/6 Nexthaler two inhalations twice a day	−4 541 648.60	−5 248 427.76
ICS+LAMA+LABA (Trimbow)	5211	247 464.50	Trelegy Ellipta	552 801.25	552 801.25

DPI, dry powder inhaler; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; LAMA, long-acting muscarinic antagonist; MDI, metered-dose inhalers; SABA, short-acting beta-agonist.