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. 2017 Nov 16;24(1):11–23. doi: 10.1177/1753425917738043

Figure 8.

Figure 8.

IL-10 secretion and inflammasome activation in THP-1 monocytes and PBMCs during H. pylori infection. (a) H. pylori-infected and E. coli LPS-primed THP-1 monocytes and PBMCs were analyzed for IL-10 secretion at early and late time points when compared with the mock control. (b) NLRP3 inflammasome activation by treating with nigericin for the last 30 min of E. coli LPS-primed THP-1 monocytes and PBMCs secreted very significant amount of mature IL-1β at the early time point (6 h); however, it was significantly down-regulated at late time point (24 h). H. pylori-infected THP-1 monocytes secreted very low amount of mature IL-1β at both time points, whereas infected PBMCs secreted significant amount at early and late time points. *P ≤ 0.05 and **P ≤ 0.005 were considered statistically significant.