Table 3.

Human equivalent doses of deferoxamine in animal models of AKI. Typical doses of DFO administered to humans range between 20 to 40 mg/kg.

^*If multiple doses were administered, the initial dose immediately before and/or immediately after injury is represented.

^**Animal-to-human conversions: mouse (12.35:1); rat (6.17:1); rabbit (3.09:1). Abbreviations: DFO, deferoxamine; HED, human equivalent dose; IA, intra-aortic; IP, intraperitoneal; IRI, ischemia-reperfusion injury; IV, intravenous; SC, subcutaneous.