Table 1.

Mixed-effects generalized linear regression model outputs for the absolute differences (%) in labelling index of CD163⁺ or calprotectin⁺ cells in the villi and crypts.

			CD163			Calprotectin
			Difference	95% CI	P-Value	Difference	95% CI	P-Value
Villi
FREpre	vs	CTRL	−2.90	−4.04, 0.32	0.066	0.27	−0.60, 4.08	0.712
FREpost	vs	CTRL	−2.42	−3.87, 1.64	0.162	−0.40	−0.75, 1.15	0.390
FREpost	vs	FREpre	0.48	−0.39, 1.91	0.337	−0.67	−0.88, −0.27	0.006
AREpre	Vs	CTRL	−2.52	−3.97, 1.90	0.171	−0.32	−0.74, 1.85	0.564
AREpost	vs	CTRL	−2.99	−4.12, 0.47	0.073	−0.48	−0.77, 1.03	0.306
AREpost	vs	AREpre	−0.48	−1.22, 0.86	0.402	−0.16	−0.36, 0.27	0.352
IREpre	vs	CTRL	−4.04	−4.43, − 2.87	<0.001	−0.25	−0.72, 1.90	0.640
IREpost	vs	CTRL	−3.61	−4.29, − 1.62	0.007	−0.39	−0.75, 1.30	0.429
IREpost	vs	IREpre	0.43	0.01, 1.14	0.045	−0.13	−0.36, 0.32	0.473
Crypts
FREpre	vs	CTRL	−3.04	−4.18, 0.35	0.066	0.15	−0.20, 1.16	0.541
FREpost	vs	CTRL	−2.09	−3.87, 3.08	0.289	−0.03	−0.26, 0.64	0.870
FREpost	vs	FREpre	0.96	−0.12, 2.73	0.090	−0.18	−0.33, 0.09	0.149
AREpre	Vs	CTRL	−2.05	−3.89, 3.46	0.315	−0.13	−0.30, 0.40	0.474
AREpost	vs	CTRL	−2.27	−3.95, 2.88	0.255	−0.14	−0.30, 0.36	0.422
AREpost	vs	AREpre	−0.20	−1.26, 1.61	0.783	−0.01	−0.12, 0.19	0.875
IREpre	vs	CTRL	−4.26	−4.57, − 3.32	<0.001	−0.16	−0.31, 0.25	0.296
IREpost	vs	CTRL	−3.87	−4.45, − 2.13	0.003	−0.21	−0.32, 0.13	0.149
IREpost	vs	IREpre	0.39	0.04, 0.98	0.023	−0.04	−0.12, 0.09	0.435

P-Value obtained with a mixed-effect generalized model incorporating dog as random effect to account for repeated measurement and Bonferroni correction for multiple comparisons. Bold values are significant P values. ARE: Antibiotic-responsive enteropathy. CI: confidence interval (Bonferroni-corrected). n: number of dogs; CTRL: healthy dogs; FRE: food responsive enteropathy; PRE: pre-treatment; POST: post-treatment; IRE: immune-suppressive responsive enteropathy.