Table 2.
Differences in ratios (expressed as fold changes) from a mixed-effects logistic regression model comparing labelling ratio of CD163 and calprotectin in villi and crypts.
|
Villi |
Crypts |
|||||||
|---|---|---|---|---|---|---|---|---|
| Group 1 | Group 2 | Fold change in ratios | (95% CI) | P-Value | Fold change in ratios | (95% CI) | P-Value | |
| FREpre | vs | CTRL | −3.5 | (−21.1, + 1.7) | 0.16 | −4.0 | (−15.1, − 1.0) | 0.048 |
| FREpost | vs | CTRL | −1.1 | (−6.6, + 5.4) | 0.92 | −1.7 | (−6.3, + 2.3) | 0.45 |
| FREpost | vs | FREpre | +3.2 | (+1.5, + 7.0) | 0.004 | +2.4 | (+1.1, + 5.1) | 0.023 |
| AREpre | vs | CTRL | −1.4 | (−9.6, + 5.0) | 0.74 | −1.2 | (−4.8, + 3.3) | 0.79 |
| AREpost | vs | CTRL | −1.2 | (−8.5, + 5.7) | 0.83 | −1.2 | (−5.0, + 3.2) | 0.75 |
| AREpost | vs | AREpre | +0.8 | (−2.3, + 2.9) | 0.81 | −1.0 | (−2.3, + 2.2) | 0.92 |
| IREpre | vs | CTRL | −5.5 | (−34.4, + 1.1) | 0.065 | −5.9 | (−21.6, − 1.6) | 0.009 |
| IREpost | vs | CTRL | −2.5 | (−15.5, + 2.5) | 0.32 | −2.6 | (−9.5, + 1.5) | 0.16 |
| IREpost | vs | IREpre | +2.5 | (1.0, + 5.1) | 0.058 | +2.3 | (+1.4, + 4.9) | 0.028 |
CI and P-values obtained with a mixed-effect generalized model incorporating dog as random effect to account for repeated measurement and additionally Bonferroni corrected for multiple comparisons. Bold values are significant P values. ARE: Antibiotic-responsive enteropathy. CI: confidence interval (Bonferroni-corrected). n: number of dogs; CTRL: healthy dogs; FRE: food responsive enteropathy; PRE: pre-treatment; POST: post-treatment; IRE: immune-suppressive responsive enteropathy. CD163+/CAL+ ratio for Group 1 and Group 2 is listed in Supplemental Table S3.