Table 1.
Single and combined (CRS) salivary biomarkers in association with clinical and radiographic periodontal parameters and the number of teeth.
|
Saliva concentration, mean (SD)a |
CRS, n (%)b |
||||||
|---|---|---|---|---|---|---|---|
| PLTP (nmol/h/ml) | LTA (pg/ml) | IL-8 (pg/ml) | MPO (ng/ml) | I | II | III | |
| Edentulous | 595.8 (454.1) | 0.345 (0.605) | 1299 (1017) | 755 (980) | 14 (60.9) | 7 (30.4) | 2 (8.7) |
| BOP% | |||||||
| 0–25 | 363.4 (386.0) | 0.263 (0.335) | 1225 (1077) | 3563 (4940) | 40 (33.9) | 43 (36.4) | 35 (29.7) |
| 26–50 | 475.3 (456.2) | 0.262 (0.515) | 1520 (1316) | 4586 (6100) | 38 (21.5) | 74 (41.8) | 65 (36.7) |
| 50–100 | 481.0 (477.0) | 0.222 (0.588) | 1416 (1173) | 6363 (8035) | 18 (17.6) | 30 (29.4) | 54 (52.9) |
| P valuec | 0.081 | 0.369 | 0.006 | < 0.001 | < 0.001 | ||
| PPD | |||||||
| < 4mm | 429.6 (400.8) | 0.138 (0.242) | 957 (1131) | 2037 (3656) | 21 (52.5) | 14 (35.0) | 5 (12.5) |
| 4–5mm | 460.0 (461.7) | 0.287 (0.508) | 1403 (1258) | 3705 (4794) | 47 (28.0) | 67 (39.9) | 54 (32.1) |
| ≥ 6mm | 432.8 (439.1) | 0.244 (0.509) | 1503 (1179) | 6278 (7736) | 28 (14.8) | 66 (34.9) | 95 (50.3) |
| P valuec | 0.416 | 0.088 | 0.001 | < 0.001 | < 0.001 | ||
| ABL | |||||||
| No | 438.9 (420.7) | 0.189 (0.267) | 1420 (1125) | 3642 (4808) | 26 (27.4) | 41 (43.2) | 28 (29.5) |
| 1/3 | 484.5 (476.1) | 0.249 (0.497) | 1396 (1297) | 4382 (6132) | 47 (27.0) | 67 (28.5) | 60 (34.5) |
| ≥ 2/3 | 391.8 (411.0) | 0.305 (0.601) | 1418 (1166) | 6140 (7650) | 23 (18.0) | 39 (30.5) | 66 (51.6) |
| P valuec | 0.285 | 0.467 | 0.164 | < 0.001 | < 0.001 | ||
| Number of teeth | |||||||
| 1–10 | 356.0 (344.8) | 0.209 (0.318) | 1110 (1502) | 2381 (3823) | 27 (45.0) | 18 (30.0) | 15 (25.0) |
| 11–20 | 373.4 (393.4) | 0.280 (0.320) | 1300 (1112) | 4367 (5988) | 12 (16.9) | 28 (39.4) | 31 (43.7) |
| 21–32 | 482.3 (472.2) | 0.254 (0.554) | 1498 (1165) | 5356 (6876) | 57 (21.4) | 101 (38.0) | 108 (40.6) |
| P valuec | 0.049 | 0.151 | < 0.001 | < 0.001 | < 0.001 | ||
aLog, logarithmic transformation preceding the ANOVA test.
bThe Chi-square test used to produce the P values.
cP value for the whole population including the edentulous patients.
ABL: alveolar bone loss; BOP: bleeding on probing; CRS: cumulative risk score; LTA: lymphotoxin-α; MPO: myeloperoxidase; PPD: probing pocket depths; PLTP: phospholipid transfer protein.Significant P values are highlighted in bold. Analyses were performed in the Parogene population (n = 455) including patients with an indication to coronary artery angiography. All patients underwent a clinical and radiographic oral examination.