Table 3.
Salivary biomarkers and CRS in association with risk haplotype.
| Periodontitis risk haplotype in either chromosome(n = 387) | Other(n = 68) | ||
|---|---|---|---|
|
Saliva concentration, mean (SD) |
P valuea | ||
| PLTP (nmol/h/ml) | 455.7 (443.7) | 420.2 (483.4) | 0.164 |
| LTA (pg/ml) | 0.261 (0.538) | 0.259 (0.334) | 0.401 |
| IL-8 (pg/ml) | 1409 (1182) | 1480 (1502) | 0.634 |
| MPO (ng/ml) | 4525 (6305) | 3894 (6237) | 0.240 |
| CRS, n (%) | P valueb | ||
| I | 91 (25.4) | 19 (30.6) | |
| II | 133 (37.2) | 21 (33.9) | 0.684 |
| III | 134 (37.4) | 22 (35.5) | |
aT-Test for comparisons between the two groups.
bChi-square test.
CRS: cumulative risk score; LTA: lymphotoxin-α; MPO: myeloperoxidase; PLTP: phospholipid transfer protein.Significant P values are highlighted in bold.
Analyses were performed in the Parogene population (n = 455) including patients with an indication to coronary artery angiography. The individuals were divided as being heterozygous for the periodontitis risk haplotype (dominant model, risk haplotype in either chromosome), or without the risk haplotype.3