Table III.
Differentially expressed genes in MDA-MB-231-GHSROS cells compared with in empty vector control cells.
| Gene symbol | Gene name | Fold-change | P-value | Affymetrix probe |
|---|---|---|---|---|
| HTR1F | 5-Hydroxytryptamine receptor 1F | 3.12 | 0.0040 | 8081067 |
| EPHA3 | EPH receptor A3 | 2.27 | 0.0190 | 8081081 |
| FKBP10 | FK506 binding protein 10 | 2.23 | 0.0032 | 8007154 |
| SHISA3 | Shisa family member 3 | 2.13 | 0.0046 | 8094870 |
| MYO1D | Myosin ID | 2.07 | 0.0111 | 8014115 |
| STK26 | Serine/threonine protein kinase 26 | 1.91 | 0.0008 | 8169949 |
| BICC1 | BicC family RNA binding protein 1 | 1.81 | 0.0021 | 7927681 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | 1.79 | 0.0106 | 7922976 |
| EPCAM | Epithelial cell adhesion molecule | 1.77 | 0.0089 | 8098439 |
| SH3BGRL2 | SH3 domain binding glutamate rich protein like 2 | 1.70 | 0.0008 | 8120833 |
| FZD3 | Frizzled class receptor 3 | 1.68 | 0.0021 | 8145611 |
| PRKAA2 | Protein kinase AMP-activated catalytic subunit α2 | 1.63 | 0.0118 | 7901720 |
| SLC16A6 | Solute carrier family 16 member 6 | 1.63 | 0.0045 | 8017843 |
| SLC4A4 | Solute carrier family 4 member 4 | 1.63 | 0.0056 | 8095585 |
| GPR63 | G protein-coupled receptor 63 | 1.62 | 0.0092 | 8128316 |
| MIPOL1 | Mirror-image polydactyly 1 | 1.62 | 0.0013 | 7973985 |
| LGR5 | Leucine rich repeat containing G protein-coupled receptor 5 | 1.58 | 0.0184 | 7957140 |
| PLCB1 | Phospholipase C β1 | 1.58 | 0.0222 | 8060854 |
| ADAM23 | ADAM metallopeptidase domain 23 | 1.56 | 0.0083 | 8047788 |
| SLITRK4 | SLIT and NTRK like family member 4 | 1.52 | 0.0070 | 8175574 |
| GNAL | G protein subunit α L | 1.52 | 0.0006 | 8020164 |
| AMOT | Angiomotin | 1.52 | 0.0128 | 8174576 |
| MGAT4A | mannosyl (α-1,3-)-glycoprotein β-1,4-N-acetylglucosaminyltransferase, isozyme A | 1.52 | 0.0418 | 8054135 |
| ULK2 | Unc-51 like autophagy activating kinase 2 | 1.50 | 0.0008 | 8013399 |
| OR2A9P///OR2A20P | Olfactory receptor family 2 subfamily A member 9 pseudogene///olfactory receptor family 2 subfamily A member 20 pseudogene | 1.50 | 0.0373 | 8136983 |
| ZNF704 | Zinc finger protein 704 | 1.50 | 0.0032 | 8151496 |
| TBX3 | T-box 3 | 1.49 | 0.0041 | 7966690 |
| SUPT20HL1/// | SPT20 homolog, SAGA complex component-like 1///SPT20 | 1.48 | 0.0245 | 8166509 |
| SUPT20HL2 | homolog, SAGA complex component-like 2 | |||
| SUPT20HL1/// | SPT20 homolog, SAGA complex component-like 1///SPT20 | 1.48 | 0.0245 | 8171844 |
| SUPT20HL2 | homolog, SAGA complex component-like 2 | |||
| TENM2 | Teneurin transmembrane protein 2 | 1.47 | 0.0391 | 8109752 |
| PDK3 | Pyruvate dehydrogenase kinase 3 | 1.47 | 0.0220 | 8166511 |
| OR2A9P///OR2A20P | Olfactory receptor family 2 subfamily A member 9 pseudogene///olfactory receptor family 2 subfamily A member 20 pseudogene | 1.47 | 0.0334 | 8143629 |
| TPD52L1 | Tumour protein D52-like 1 | 1.46 | 0.0024 | 8121838 |
| TMEM56-RWDD3/// | TMEM56-RWDD3 readthrough///transmembrane | 1.46 | 0.0363 | 7903162 |
| TMEM56 | protein 56 | |||
| CLEC2B | C-type lectin domain family 2 member B | 1.45 | 0.0498 | 7961083 |
| CSF3 | Colony stimulating factor 3 | 1.45 | 0.0052 | 8006999 |
| PICK1 | Protein interacting with PRKCA 1 | −1.47 | 0.0386 | 8072989 |
| MAOA | Monoamine oxidase A | −1.48 | 0.0217 | 8166925 |
| CRISPLD1 | Cysteine rich secretory protein LCCL domain containing 1 | −1.49 | 0.0009 | 8146967 |
| MSLN | Mesothelin | −1.50 | 0.0059 | 7992071 |
| ZNF558 | Zinc finger protein 558 | −1.53 | 0.0070 | 8033667 |
| PTPN22 | Protein tyrosine phosphatase, non-receptor type 22 | −1.54 | 0.0004 | 7918657 |
| NDP | NDP, norrin cystine knot growth factor | −1.54 | 0.0004 | 8172220 |
| IFI27 | Interferon α inducible protein 27 | −1.56 | 0.0225 | 7976443 |
| ZNF814 | Zinc finger protein 814 | −1.56 | 0.0033 | 8039692 |
| PARP15 | poly(ADP-ribose) polymerase family member 15 | −1.56 | 0.0147 | 8082086 |
| CPT1C | Carnitine palmitoyltransferase 1C | −1.56 | 0.0267 | 8030448 |
| RNU5D-1 | RNA, U5D small nuclear 1 | −1.57 | 0.0412 | 7915592 |
| ARHGAP6 | Rho GTPase activating protein 6 | −1.58 | 0.0042 | 8171313 |
| MEST | Mesoderm specific transcript | −1.63 | 0.0026 | 8136248 |
| STOM | stomatin | −1.67 | 0.0110 | 8163896 |
| NLRP2 | NLR family pyrin domain containing 2 | −1.72 | 0.0001 | 8031398 |
| MUSK | Muscle associated receptor tyrosine kinase | −1.79 | 0.0389 | 8157173 |
| CSF2RA | Colony stimulating factor 2 receptor α subunit | −1.80 | 0.0030 | 8165735 |
| CSF2RA | Colony stimulating factor 2 receptor α subunit | −1.80 | 0.0030 | 8176306 |
| LYPD6B | LY6/PLAUR domain containing 6B | −1.97 | 0.0188 | 8045664 |
| TENM1 | Teneurin transmembrane protein 1 | −1.97 | 0.0238 | 8174937 |
| TGIF2LY/// | TGFB induced factor homeobox 2 like, Y-linked///TGFB | −1.97 | 0.0002 | 8176397 |
| TGIF2LX | induced factor homeobox 2 like, X-linked | |||
| HLA-DPB1 | Major histocompatibility complex, class II, DP β1 | −1.99 | 0.0485 | 8118594 |
| TGIF2LY/// | TGFB induced factor homeobox 2 like, Y-linked///TGFB | −1.99 | 0.0002 | 8168646 |
| TGIF2LX | induced factor homeobox 2 like, X-linked | |||
| ADGRF1 | Adhesion G protein-coupled receptor F1 | −2.00 | 0.0038 | 8126820 |
| SLC38A4 | Solute carrier family 38 member 4 | −2.04 | 0.0081 | 7962559 |
| HLA-DPB1 | Major histocompatibility complex, class II, DP β1 | −2.07 | 0.0403 | 8178220 |
| SPANXC///SPANXD | SPANX family member C///SPANX family member D | −2.10 | 0.0027 | 8175558 |
| HLA-DPA1 | Major histocompatibility complex, class II, DP α1 | −2.22 | 0.0466 | 8125556 |
| HLA-DPA1 | Major histocompatibility complex, class II, DP α1 | −2.22 | 0.0466 | 8178891 |
| HLA-DPA1 | Major histocompatibility complex, class II, DP α1 | −2.22 | 0.0470 | 8180100 |
| HLA-DPB1 | Major histocompatibility complex, class II, DP β1 | −2.31 | 0.0391 | 8179519 |
| ZNF585B | zinc finger protein 585B | −2.31 | 0.0001 | 8036389 |
| HLA-DRA/// | Major histocompatibility complex, class II, DR α///major | −2.35 | 0.0065 | 8118548 |
| HLA-DQA1 | histocompatibility complex, class II, DQ α1 | |||
| HLA-DRA/// | Major histocompatibility complex, class II, DR α///major | −2.36 | 0.0058 | 8179481 |
| HLA-DQA1 | histocompatibility complex, class II, DQ α1 | |||
| LOC645188 | Uncharacterised LOC645188 | −2.39 | 0.0003 | 8170257 |
| HLA-DRA/// | Major histocompatibility complex, class II, DR α///major | −2.55 | 0.0072 | 8178193 |
| HLA-DQA1 | histocompatibility complex, class II, DQ α1 | |||
| LOC105369230/// | HLA class II histocompatibility antigen, DRB1-7β chain///major | −2.62 | 0.0054 | 8180003 |
| HLA-DRB6/// | histocompatibility complex, class II, DR β6 (pseudogene)///major | |||
| HLA-DRB5/// | histocompatibility complex, class II, DR β5///major | |||
| HLA-DRB4/// | histocompatibility complex, class II, DR β4///major | |||
| HLA-DRB3/// | histocompatibility complex, class II, DR β4///major | |||
| HLA-DRB1/// | histocompatibility complex, class II, DR β3///major | |||
| LOC105369230/// | histocompatibility complex, class II, DR β1///HLA class II | |||
| HLA-DRB5/// | histocompatibility antigen, DRB1-7β chain///major | |||
| HLA-DRB4/// | histocompatibility complex, class II, DR β5///major | |||
| HLA-DRB3/// | histocompatibility complex, class II, DR β4///major | |||
| HLA-DRB1/// | histocompatibility complex, class II, DR β3///major | |||
| HLA-DQB1 | histocompatibility complex, class II, DR β1///major histocompatibility complex, class II, DQ β1 | |||
| LOC105369230/// | HLA class II histocompatibility antigen, DRB1-7 β chain///major | −2.66 | 0.0063 | 8178811 |
| HLA-DRB6/// | histocompatibility complex, class II, DR β6 (pseudogene)///major | |||
| HLA-DRB5/// | histocompatibility complex, class II, DR β5///major | |||
| HLA-DRB4/// | histocompatibility complex, class II, DR β4///major | |||
| HLA-DRB3/// | histocompatibility complex, class II, DR β3///major | |||
| HLA-DRB1/// | histocompatibility complex, class II, DR β1///HLA class II | |||
| LOC105369230/// | histocompatibility antigen, DRB1-7β chain///major | |||
| HLA-DRB5/// | histocompatibility complex, class II, DR β5///major | |||
| HLA-DRB4/// | histocompatibility complex, class II, DR β4///major | |||
| HLA-DRB3/// | histocompatibility complex, class II, DR β3///major | |||
| HLA-DRB1/// | histocompatibility complex, class II, DR β1///major | |||
| HLA-DQB1 | histocompatibility complex, class II, DQ β1 | |||
| LOC105369230/// | HLA class II histocompatibility antigen, DRB1-7β chain///major | −2.71 | 0.0068 | 8178802 |
| HLA-DRB6/// | histocompatibility complex, class II, DR β6 (pseudogene)///major | |||
| HLA-DRB5/// | histocompatibility complex, class II, DR β5///major | |||
| HLA-DRB4/// | histocompatibility complex, class II, DR β4///major | |||
| HLA-DRB3/// | histocompatibility complex, class II, DR β3///major | |||
| HLA-DRB1/// | histocompatibility complex, class II, DR β1///HLA class II | |||
| LOC105369230/// | histocompatibility antigen, DRB1-7β chain///major histocompatibility | |||
| HLA-DRB5/// | complex, class II, DR β5///major histocompatibility complex, | |||
| HLA-DRB4/// | class II, DR β4///major histocompatibility complex, class II, | |||
| HLA-DRB3/// | DR β3///major histocompatibility complex, class II, DR β1///major | |||
| HLA-DRB1///HLA-DQB1 | histocompatibility complex, class II, DQ β1 |
Bold text represents higher expression in MDA-MB-231-GHSROS cells; unbold text represents lower expression in MDA-MB-231-GHSROS cells. P-values were obtained using the R package 'limma' (moderated t-test).