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. 2019 Sep 30;55(6):1296–1312. doi: 10.3892/ijo.2019.4887

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Copyright: © Ye et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Anisomycin affects the expression of PDGFRs and Notch pathway components in ovarian cancer stem cells. (A) mRNA expression levels of key factors of the Notch pathway, PDGFRA and PDGFRB in ovarian cancer tissues with more and less CD44⁺/CD133⁺ HuOCSCs. ^**P<0.01. (B) mRNA expression levels of key factors of the Notch pathway, PDGFRA and PDGFRB in CD44⁺/CD133⁺ HuOCSCs following anisomycin treatment. ^**P<0.01 vs. non-treated (n=4). (C) Western blotting results from the experimental groups of panel A. (D) Western blotting results from the experimental groups of panel B. PDGFR, platelet-derived growth factor receptor; HuOCSCs, human ovarian cancer stem cells; DLL1, δ-like canonical Notch ligand 1; HES1, hes family bHLH transcription factor 1; RBPJ, recombination signal binding protein for immunoglobulin κ J region.