Figure 3.

Local gene delivery restores hearing. Auditory brainstem response (ABR) thresholds in response to click sounds (A), tone burst at 8 kHz (B), 16 kHz (C) and 32 kHz (D) tone bursts in Slc26a4^+/+, Slc26a4^Δ/Δ, injected Slc26a4^Δ/Δ, Slc26a4^{tm1Dontuh/tm1Dontuh}, and injected Slc26a4^{tm1Dontuh/tm1Dontuh} mice at 3 to 5 weeks of age. Data are drawn as symbols and represented by box-plots (25%, 50%, and 75%) with whiskers (5% and 95%). Brackets mark comparisons among types of mice. Significance was evaluated by Kruskal-Wallis one-way ANOVA on ranks with Dunn's method: n.s. no significant difference, * p<0.05, ** p<0.01, *** p<0.001