Figure 7.

Free DOX biodistribution and antitumor efficiency after decreasing tumor IFP and solid stress in vivo. Time course of DOX concentration in the plasma of H22 tumor-bearing mice with and without pretreatment (A); Biodistribution of DOX in H22 tumor-bearing mice without pretreatment (B) and with pretreatment (C), data is represented as mean ± SD (N = 3); Accumulation of DOX in tumor calculated as area-under-the-curve (AUC) (D); In vivo tumor growth curves (E) and survival number (F) of H22 tumor-bearing mice with and without pretreatment, data is represented as mean ± SD (N = 10). (** represents P < 0.01).