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Schematic illustrations of CES-cleavable biotinylated nanoparticle for tumor-dual targeted imaging. NIR probe NIR-CBT is subjected to reduction-controlled condensation and self-asssembly to form biotinylated, fluorescence-quenched nanoparticle NIR-CBT-NP. NIR-CBT-NP targets and translocates the biotin receptor-overexpressing tumor cells and its fluorophore Cy5.5 is subsequently cleaved by intracellular CES, turning the NIR fluorescence signal “On”.
