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. 2019 Sep 21;9(24):7108–7121. doi: 10.7150/thno.38182

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4-aminobiphenyl (4-ABP) activates the PI3K-Akt pathway in umbilical cord mesenchymal stem cells (UC-MSC). (A-C) Bioinformatic Venn diagram (A), KEGG (B) and Heatmap (C) analyses of the key molecules and signaling pathways differentially regulated in UC-MSC treated with kartogenin (KGN) or 4-ABP (10 μM) for 3 days based on transcriptome analysis. (D-E) p-ERK1/2, p-AKT, p-JUN, p-RSK-3 and CDK-2 protein expression in UC-MSC treated with vehicle, KGN or 4-ABP (10 μM) for 3 days. **p < 0.01, ***p < 0.001 versus vehicle; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus KGN. n = 3 per group. (F) p-RSK-3 expression in cartilage from C57BL/6J mice subjected to destabilization of medial meniscus surgery. Scale bars = 100 μm. **p < 0.01, ***p < 0.001 versus sham. n = 5 per group.