Figure 6.

The combination of nCUR/nSN38 nanotherapeutics prevents the tumorigenesis and growth of CAC in vivo. (A) The establishment of an inflammation-driven colon cancer model in C57BL/6 mice and the therapeutic protocols of nCUR/nSN38. The mice received a single injection of AOM via the tail vein followed by supplementation with three cycles of 2% DSS. (B) Representative images of murine colons. (C-E) Tumor numbers per mouse (C), tumor diameters (D), and tumor size distribution (E) were measured in each group. (F) H&E staining of tumor morphology. The green arrows and dotted circles indicate crypts and leukocyte infiltration, respectively. The data are presented as the mean ± SD (n =12). *p < 0.05 and **p < 0.01, as determined by two-way ANOVA followed by Bonferroni's post hoc test.