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. 2019 Oct 12;9(25):7583–7598. doi: 10.7150/thno.37717

Figure 7.

Figure 7

Immunohistochemical staining for FOXO1, β-catenin and HBX expression and in situ hybridization analysis of miR-5188. (A) Comparison of β-catenin and FOXO1 expression between HCC and para-carcinoma tissues from data in TCGA database (Wilcoxon rank sum test). (B) Kaplan-Meier survival analysis of HCC patients based on FOXO1 expression from data in TCGA database (log-rank test). (C) Representative immunohistochemical images of β-catenin and FOXO1 expression between HCC tissues and para-carcinoma tissues. (D) Correlations among FOXO1, β-catenin, HBX and miR-5188 expression (representative in situ hybridization images) (Spearman's rank correlation test). (E) Kaplan-Meier survival analysis of HCC patients based on FOXO1 expression (log-rank test). (F) Kaplan-Meier survival analysis of HCC patients based on miR-5188 and FOXO1 expression (log-rank test). (G) Working model of miR-5188-FOXO1/β-catenin-c-Jun feedback loop induced by the hepatitis B X protein through Wnt signaling in hepatocellular carcinoma. Lines indicate median values, and whiskers indicate minimum and maximum values (A).