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Schematic of the process of the Sipuleucel-T therapy against prostate cancer. The monocytes were harvested from the patients and treated with the fusion protein, and re-infused into the patients. The infused monocytes could differentiate to the APCs, which activated the PAP-specific CD4+ and CD8+ T cells to kill the prostate cancer cells. Reprinted with permission from ref 113. Copyright 2011 SAGE Publications.
