Figure 6.

Schematic of the artificially reprogrammed HION@Mac for cancer therapy. Reprinted with permission from ref 138. HION@Mac was obtained by the macrophage internalizing HION, the hyaluronic acid-coated iron oxide nanoparticles. HION@Mac after injection could migrate to the tumor with expression of inflammatory factors via chemotaxis of the macrophage. In the tumor tissue, HION@Mac not only induced tumor cell apoptosis by releasing ROS and inflammatory factors, but also facilitated the polarization from the TAMs to the M1-type macrophages for enhanced antitumor efficacy. Copyright 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.