Figure 7.

Schematic of the modification of cytokine nanogel on the T cell surface for cancer immunotherapy. IL-15 was self-crosslinked to prepare the IL-15 nanogel, which was subsequently modified with the anti-CD45 antibodies and the cationic PEG-b-PLL polymer. The surface-modified IL-15 nanogels could be stably attached on the surface of T cells via a combination of electronic and antibody-receptor interactions. The obtained T cell backpack showed superior effects in augmenting immunotherapeutic efficacy. Reprinted with permission from ref 146. Copyright 2018 Springer Nature.