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. 2019 Oct 12;9(25):7537–7555. doi: 10.7150/thno.38913

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Effect of GDC-0449 and MDB5 loaded micelles in CBDL induced liver fibrosis. (A) Alanine transaminase (ALT). (B) Aspartate transaminase (AST). (C) Total bilirubin (TBIL). (D) Alkaline phosphatase (ALP) levels after treatment. Results are presented as the mean ± S.D. (n = 4). A t-test was used to compare different groups, and p<0.05 was considered statistically significant. *: P<0.05 between the two groups. (E) Representative macroscopic pictures of livers from CBDL mice after systemic administration of micelles loaded with GDC-0449 or MDB5 (upper first panel). H&E staining representing damaged liver architecture after CBDL (upper second panel, yellow arrows). Collagen specific Masson's trichrome (MT) (Third panels), and Sirius red staining (fourth panel) of liver sections. Treatment with GDC-0449 and MDB5 loaded micelles reduced collagen staining (original magnification, ×10).