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. 2019 Oct 15;9(25):7807–7825. doi: 10.7150/thno.37194

Figure 1.

Figure 1

TAM-targeted immunotherapies for the treatment of cancer. A,B) Schematic of the combined siRNA-silencing therapy and immunotherapy targeting TAMs and cancer cells in vivo using RNAi/Peptide nanoparticles (NPs) administered directly to bronchial airways. C) Immunofluorescence microscopy images of recovered macrophages from BAL fluid show RNAi/Peptide NPs (green) internalization and VEGF (red) expression. D,E) Survival curves of untreated control (sham, in black) and RNAi NPs (gray) and RNAi/Peptide NPs (green) mice using two dosages. Adapted with permission from 32, copyright 2015, Wiley-VCH.