Figure 11.
Peptide-based nanogels and their use as immunologic agents against cancer. A) Formation and the mechanism of action for the DC-based vaccine nodule engineered in a nanofibrous peptide hydrogel. Delivery of exogenous DCs and recruitment of host DCs in vivo by the vaccine nodule. B) Representative scatter plots illustrating the identification of MHCII+CD11c+ DCs (in red rectangle) recovered from gels and C) quantification of MHCII+CD11c+ DCs in gels at various time points. D) Representative optical sectioning of dLNs explanted at day 1 after injection. DCs in the dLNs are indicated by GFP (green), and the nuclei of T cells were stained by DAPI (blue). Adapted with permission from 51, copyright 2018 American Chemical Society.