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. 2019 Aug 11;32(4):319–327. doi: 10.1293/tox.2019-0022

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©2019 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/）.

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Fig. 1. — Quantification of hepatocellular degeneration/necrosis area. (a, c, e, g) Original images. (b, d, f, h) Segmented images of degeneration/necrosis (green), red blood cells (red), and the other regions (pink) through the use of the tissue classifier module. (g, h) Enlarged images of blue frames in (e) and (f), respectively. Grade of degeneration/necrosis evaluated by pathologists: (a, b) no change, −; (c, d) slight, +; (e–h) moderate, ++. Bar = 1 mm. (i) Quantitative results for degeneration/necrosis area (% of the whole area of the liver section).