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. 2019 Apr 25;21(11):2552–2560. doi: 10.1038/s41436-019-0522-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Correspondence of biochemical change with IQ outcome. Percent change in IQ from baseline (i.e., pretreatment) to 2-year posttransplant anniversary is plotted against percent reduction in nonreducing end (NRE) I0S6 from time point 1 to 4, i.e., pretreatment through final intrathecal recombinant iduronidase infusion occurring 6 months posttransplant (N = 15). A significant association was found, such that percent decrease in I0S6 was significantly associated with more favorable change in IQ (p = 0.0035). CI confidence interval.