Table 4.

Multivariable survival analysis

Variable	Hazard ratio	95% CI	p value
Age, years	1.00	1.00–1.01	0.417
ASA III/IV	1.05	0.86–1.28	0.636
R1 margin	1.48	1.12–1.95	0.005
Lymph node metastases	1.88	1.48–2.39	< 0.001
Direct expansion other organ	1.63	1.17–2.29	0.004
Perineural invasion	1.18	0.89–1.56	0.256
Major vascular invasion	1.04	0.76–1.43	0.793
Size, cm	1.05	1.02–1.07	< 0.001
Lesion number
Single lesion	Ref	–	–
2 lesions	1.19	0.90–1.57	0.229
> 2 lesions	1.97	1.48–2.64	< 0.001