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Numbers of common and rare haplotype alleles in genes of folate metabolism (human genome assembly GRCh37/hg19; rare haplotypes have frequency below 1%). *, GNMT is the enzyme regulated by folate. Red box indicates four enzymes of the mitochondrial glycine cleavage system, #, the folate dependent enzyme in glycine cleavage. Haplotypes were analyzed using UCSC Genome Browser (https://genome.ucsc.edu).
