Table 2.

Mendelian randomization associations of blood lead (effect sizes of log transformed blood lead) based on 11 (rs16968074 and rs550057 excluded) independent SNPs (p-value < 5 × 10⁻⁶) with CAD using a study largely based on CARDIoGRAPMplusC4D 1000 Genomes and the UK Biobank SOFT CAD, with diabetes using Diagram, and with blood pressure using the UK Biobank.

Outcome	Mendelian Randomization Method	Odds ratio	95% confidence interval	p-value	Cochran’s Q statistic (p-value)	MR-Egger
						Intercept p-value	I2
CAD	Inverse variance weighted	1.01	0.96 to 1.05	0.82	9.9 (0.45)
	Weighted median	1.01	0.95 to 1.07	0.87
	MR-Egger	1.05	0.95 to 1.16	0.38	9.1 (0.43)	0.38	27%
	MR-PRESSO (corrected)	1.01	0.96 to 1.05
Diabetes	Inverse variance weighted	0.98	0.91 to 1.04	0.50	8.6 (0.57)
	Weighted median	0.98	0.90 to 1.07	0.68
	MR-Egger	0.99	0.85 to 1.14	0.87	8.5 (0.48)	0.86	1%
	MR-PRESSO (corrected)	0.98	0.92 to 1.04
		β
SBP	Inverse variance weighted	−0.20	−0.46 to 0.07	0.14	13.1 (0.22)
mmHg	Weighted median	−0.32	−0.64 to 0.004	0.05
	MR-Egger	−0.26	−0.88 to 0.38	0.43	13.0 (0.16)	0.84	17.7%
	MR-PRESSO	−0.20	−0.46 to 0.07
DBP	Inverse variance weighted	0.02	−0.11 to 0.15	0.77	8.9 (0.54)
mmHg	Weighted median	−0.03	−0.21 to 0.14	0.75
	MR-Egger	0.12	−0.18 to 0.42	0.32	12.7 (0.18)	0.44	18.7%
	MR-PRESSO (corrected)	0.02	−0.11 to 0.15

rs9863067 replaced by proxy rs7625182 for diabetes.