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. 2019 Nov 5;9:16062. doi: 10.1038/s41598-019-51905-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Collagen turnover biomarkers in Clusters 2–4.Collagen fragments reflecting degradation and formation processes of (A) COL I, (B) COL III, (C) COL IV, and (D) COL VI were shown for patients in Cluster 2–4. Data are presented as percentage of the average biomarker levels in Cluster 3 and depicted as scatter plot with median. Differences between groups was assessed by a Kruskal-Wallis test with Dunn’s multiple comparisons test. Significance level: *p < 0.05, ^†p < 0.01, ^‡p < 0.001, ^§p < 0.0001.