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. 2019 Nov 5;9:16059. doi: 10.1038/s41598-019-52558-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Zebrafish embryonic valves can regenerate. (A–C) Confocal z-stacks of untreated Tg(hspGFFDMC73A/UAS-E1b:NfsB-mCherry) larvae at 4 dpf, 6 dpf and 12 dpf respectively. (D–F) Confocal z-stacks of MTZ treated Tg(hspGFFDMC73A/UAS-E1b:NfsB-mCherry) and larvae at 4 dpf, 6 dpf and 12 dpf respectively. Arrows show the ablation of mCherry+ cells at the AV canal and OFT at 4 dpf. From 6 dpf more mCherry+ cells could be observed at the AV canal. By 12 dpf the regeneration process could be imaged, as mCherry+, AV differentiated cells were present at both valves. Scale bars: 20 microns. Each experiment was carried out at least 3 independent times with n = 10 embryos per experimental group.