TABLE 6.
Results of GEE analysis (repeated measurement) with the Daily Record of Severity of Problems (DRSP) total score and subscale scores as dependent variables.
| Dependent variables | Exploratory variables | B | SE | Wald X2 | df | p |
| Sum DRSP (T1→T4) | Oestradiol (T1→T4) | 0.022 | 0.025 | 0.80 | 1 | 0.370 |
| Progesterone (T1→T4) | –0.076 | 0.023 | 10.79 | 1 | 0.001 | |
| Sum DRSP (T1→T4) | Oestradiol (T1→T4) | –0.059 | 0.022 | 6.92 | 1 | 0.009 |
| Progesterone T1−(T2 + T3 + T4) | 0.082 | 0.023 | 12.80 | 1 | <0.001 | |
| Sum DRSP (T1→T4) | Prog_lag | 0.084 | 0.039 | 4.76 | 1 | 0.029 |
| Sum DRSP (T1→T4) | ΔProg_lag | –0.075 | 0.025 | 9.34 | 1 | 0.002 |
| Sum DRSP (T1→T4) | Progesteron T2 + T3 + T4 | –0.116 | 0.020 | 35.11 | 1 | <0.001 |
| Prog_lag | 0.118 | 0.037 | 10.49 | 1 | 0.001 | |
| Sum DRSP (T1→T4) | Progesteron T2 + T3 + T4 | –0.081 | 0.023 | 12.52 | 1 | <0.001 |
| ΔProg_lag | –0.074 | 0.025 | 8.87 | 1 | 0.003 | |
| Depression (T1→T4) | Oestradiol (T1→T4) | –0.059 | 0.021 | 7.74 | 1 | 0.005 |
| Progesterone T1−(T2 + T3 + T4) | 0.096 | 0.022 | 20.01 | 1 | <0.001 | |
| Depression (T1→T4) | Progesterone T1−(T2 + T3 + T4) | 1.423 | 0.368 | 14.96 | 1 | <0.001 |
| ΔProg_lag | –0.048 | 0.019 | 6.05 | 1 | 0.014 | |
| Physio-somatic (T1→T4) | Oestradiol (T1→T4) | –0.061 | 0.030 | 4.02 | 1 | 0.045 |
| Progesterone T1−(T2 + T3 + T4) | 0.076 | 0.030 | 6.25 | 1 | 0.012 | |
| Physio-somatic (T1→T4) | Progesterone T2 + T3 + T4 | –0.971 | 0.299 | 10.50 | 1 | 0.001 |
| Prog_lag | 1.410 | 0.574 | 6.03 | 1 | 0.014 | |
| Anxiety (T1→T4) | Progesterone T2 + T3 + T4 | –0.979 | 0.365 | 7.22 | 1 | 0.007 |
| Prog_lag | 0.929 | 0.404 | 5.28 | 1 | 0.022 | |
| Eating-& Breast (T1→T4) | Progesterone T2 + T3 + T4 | –0.517 | 0.131 | 15.50 | 1 | <0.001 |
| Prog_lag | 1.09 | 0.423 | 6.60 | 1 | 0.010 | |
| Eating-& Breast (T1→T4) | Oestradiol (T1 + T2 + T3 + T4) | –0.211 | 0.072 | 8.54 | 1 | 0.003 |
| Prog_lag | 1.023 | 0.420 | 5.92 | 1 | 0.015 | |
| Progesterone (T1→T4) | Oestradial (T1 + T2 + T3 + T4) | 0.167 | 0.040 | 17.74 | 1 | <0.001 |
| Δoestradiol_lag | –0.383 | 0.101 | 14.26 | 1 | <0.001 | |
| Time | 1.478 | 0.354 | 187.79 | 1 | <0.001 |
T1→T4: denotes the repeated measurements over four time points. T1−(T2 + T3 + T4): computed as a z unit weighted composite score. T1 + T2 + T3 + T4: sum of the z scores of the four time points. T2 + T3 + T4: sum of the z scores of the three time points in the luteal phase. Prog_log: lagged progesterone values (1 week lag). ΔProg_lag and Δoestradiol_lag: delta values of current hormonal values – lagged hormonal values (1 week lag).