FIGURE 2.

(A) Mean arterial blood pressure (MAP), (B) heart rate (HR), (C) arterial oxygen tension (pO₂), (D) arterial partial pressure of carbon dioxide (pCO₂), (E) arterial pH, and (F) arterial lactate during the long-term hypoxia protocol. (G) Shows the HbO₂ saturation calculated from the pO₂ and the Hill equation for HbO₂ dissociation with and without 5-HMF. The p50 value used for the 5-HMF treated and vehicle groups are shown in Table 1. Symbols represent statistically significant differences (P < 0.05): ^∗ relative to 21% FiO₂, † relative to 15% FiO₂, and ‡ relative to 10% FiO₂.