Fig. 2.

Effect of PTE on the anticonvulsant activity of CBZ (a) and TPM (b) in the MES test in mice. PTE and CBZ were administered 30 min, while TPM 60 min before the MES test. All the drugs were administered ip at a constant volume of 10 ml per kg body weight. Animals in the control group received antiepileptic drug (CBZ or TPM) alone, while other experimental groups received the respective antiepileptic drug in combination with PTE. Data are presented as ED doses (the doses which protect 50% of the tested animals from the maximal electroshock convulsions) + SEM and were analyzed using one-way ANOVA (CBZ F(3,68) = 9.70, p < 0.0001; TPM F(3,68) = 1.16, p = 0.333) with the Tukey post hoc test. **p < 0.01, ***p < 0.001 vs. control (CBZ-treated) group. CBZ, carbamazepine; PTE, pterostilbene, TPM, topiramate