Fig. 3.

Effect of PTE on the anticonvulsant activity of VPA (a) and OXC (b) in the 6 Hz psychomotor seizure test in mice. VPA was administered 15 min, while PTE and OXC 30 min before the 6 Hz test. All the drugs were administered ip at a constant volume of 10 ml per kg body weight. Animals in the control group received antiepileptic drug (VPA or OXC) alone, while other experimental groups received the respective antiepileptic drug in combination with PTE. Data are presented as ED doses (the doses which protect 50% of the tested animals from the psychomotor seizures) + SEM and were analyzed using one-way ANOVA (VPA F(3,69) = 4.43, p = 0.007; OXC F(3,68) = 5.31, p = 0.002) with the Tukey post hoc test. **p < 0.01 vs. control (OXC-treated) group. OXC, oxcarbazepine; PTE, pterostilbene; VPA, valproate