Table 1.
Influence of the studied antiepileptic drugs and their combinations with PTE on the muscular strength and motor coordination in mice
| Treatment (mg/kg) | Neuromuscular strength (mN/g) | Impairment of motor coordination (%) | N |
|---|---|---|---|
| A | |||
| Control (5% Tween) | 28.80 ± 1.1 | 0 | 12 |
| CZP (0.04) | 28.31 ± 1.6 | 0 | 12 |
| CZP (0.04) + PTE (25) | 26.25 ± 1.1 | 0 | 11 |
| CZP (0.04) + PTE (50) | 27.71 ± 0.9 | 0 | 12 |
| CZP (0.04) + PTE (100) | 27.99 ± 1.2 | 0 | 12 |
| One-way ANOVA F(4,54) = 0.604, p = 0.661 | |||
| B | |||
| Control (5% Tween) | 29.09 ± 1.8 | 0 | 12 |
| TGB (5) | 29.18 ± 0.9 | 0 | 12 |
| TGB (5) + PTE (25) | 29.37 ± 0.9 | 9 | 11 |
| TGB (5) + PTE (50) | 28.66 ± 1.1 | 8 | 12 |
| TGB (5) + PTE (100) | 28.23 ± 0.9 | 0 | 12 |
| One-way ANOVA F(4,55) = 0.16, p = 0.958 | |||
| C | |||
| Control (5% Tween) | 30.60 ± 0.9 | 0 | 10 |
| CBZ (5.9) | 30.38 ± 1.1 | 0 | 10 |
| CBZ (5.9) + PTE (100) | 26.72 ± 1.1*# | 10 | 10 |
| One-way ANOVA F(2,27) = 4.56, p = 0.020 | |||
| D | |||
| Control (5% Tween 80) | 32.49 ± 0.9 | 0 | 10 |
| TPM (29.4) | 30.45 ± 1.3 | 0 | 10 |
| TPM (29.4) + PTE (100) | 31.20 ± 1.0 | 0 | 10 |
| One-way ANOVA F(2,27) = 0.93, p = 0.409 | |||
| E | |||
| Control (5% Tween) | 28.53 ± 1.2 | 0 | 10 |
| VPA (93) | 28.09 ± 1.7 | 0 | 10 |
| VPA (93) + PTE (100) | 26.20 ± 1.1 | 0 | 10 |
| One-way ANOVA F(2,27) = 0.82, p = 0.451 | |||
| F | |||
| Control (5% Tween) | 30.60 ± 0.9 | 0 | 10 |
| OXC (9.02) | 31.77 ± 1.5 | 0 | 10 |
| OXC (9.02) + PTE (100) | 30.48 ± 1.0 | 0 | 10 |
| One-way ANOVA F(2,27) = 0.39, p = 0.683 | |||
VPA and TGB were administered 15 min before the tests, PTE, CBZ, OXC, and CZP, 30 min, while TPM, 60 min. Control group received the vehicle. All solutions/suspensions were injected ip. Each experimental group consisted of 10–12 animals. Results from the grip strength test are presented as the mean ± SEM grip strengths in millinewtons per gram of mouse body weight (mN/g) and were analyzed with one-way ANOVA followed by the Tukey post hoc test. Data from the chimney test are presented as a percentage of animals with impairment of motor coordination and were compared using the Fisher exact probability test. *p < 0.05 vs. control (5% Tween-treated) group; #p < 0.05 vs. CBZ-treated group. CBZ carbamazepine, CZP clonazepam, OXC oxcarbazepine, PTE pterostilbene, TGB tiagabine, VPA valproate