Table 2.

Effect of PTE on serum and total brain concentration of CZP, CBZ and OXC

Treatment (mg/kg)	Serum concentration	Total brain concentration
A
CZP (0.04)	16.40 ± 2.12 (ng/ml)	4.45 ± 0.61 (ng/g tissue)
CZP (0.04) + PTE (100)	14.28 ± 1.20 (ng/ml)	4.40 ± 0.32 (ng/g tissue)
	Student’s t test: p = 0.1977	Student’s t test: p = 0.4705
B
CBZ (5.9)	2.06 ± 0.10 (μg/ml)	3.72 ± 0.45 (μg/g tissue)
CBZ (5.9) + PTE (100)	2.41 ± 0.06 (μg/ml)**	5.45 ± 0.36 (μg/g tissue)**
	Student’s t test: p = 0.0043	Student’s t test: p = 0.0039
C
OXC (9.02)	2.97 ± 0.19 (μg/ml)	3.46 ± 0.27 (μg/g tissue)
OXC (9.02) + PTE (100)	4.23 ± 0.46 (μg/ml)*	5.47 ± 0.58 (μg/g tissue)**
	Student’s t test: p = 0.0104	Student’s t test: p = 0.0027

PTE, CZP, CBZ, and OXC were administered ip 30 min before the samples collection. Each experimental group consisted of 10 mice. Results are presented as the mean ± SEM. Serum and brain concentrations of the studied antiepileptic drugs were analyzed using the Student t test. *p < 0.05, **p < 0.01 vs. control (treated with antiepileptic drug alone) group. CBZ carbamazepine, CZP clonazepam, OXC oxcarbazepine, PTE pterostilbene