Table 1.
Respiratory mechanics
| PC (n = 9) | AC (n = 10) | PS100 (n = 9) | PS60 (n = 10) | PS20 (n = 10) | Main effect | |||
|---|---|---|---|---|---|---|---|---|
| Within group | Between group | |||||||
| PAW [cmH2O] | BL | 15 ± 3 | 15 ± 4 | 13 ± 2 | 14 ± 3 | 13 ± 1 | ||
| ALI-BL | 22 ± 4 | 22 ± 4 | 18 ± 3 | 20 ± 4 | 21 ± 1 | |||
| ALI-End | 26 ± 6#* | 25 ± 7 | 19 ± 7 | 15 ± 5* | 9 ± 3#* | 0.060 | 0.000 | |
| PTPinsp [cmH2O] | BL | 16 ± 4 | 15 ± 4 | 13 ± 4 | 14 ± 4 | 13 ± 5 | ||
| ALI-BL | 22 ± 5 | 23 ± 4 | 20 ± 6 | 19 ± 6 | 19 ± 4 | |||
| ALI-End | 25 ± 7 | 26 ± 7 | 24 ± 9 | 23 ± 6 | 23 ± 8 | 0.006 | 0.987 | |
| PTPexp [cmH2O] | BL | 5 ± 3 | 4 ± 2 | 4 ± 3 | 6 ± 2 | 4 ± 4 | ||
| ALI-BL | 4 ± 3 | 5 ± 2 | 6 ± 5 | 4 ± 3 | 3 ± 3 | |||
| ALI-End | 5 ± 4 | 5 ± 4 | 6 ± 4 | 4 ± 2 | 3 ± 6 | 0.790 | 0.337 | |
| VT [ml/kg BW] | BL | 9.6 ± 1.2 | 8.7 ± 0.8 | 8.7 ± 0.6 | 8.8 ± 1 | 8.6 ± 0.9 | ||
| ALI-BL | 8.4 ± 1.6 | 9.4 ± 2.0 | 8.9 ± 2.8 | 11 ± 4 | 8.6 ± 1.9 | |||
| ALI-End | 9.0 ± 1.2 | 9.0 ± 1.2 | 9.1 ± 1.0 | 10 ± 3 | 8.9 ± 1.2 | 0.919 | 0.853 | |
| RR [min−1] | BL | 77 ± 18 | 81 ± 15 | 84 ± 8 | 87 ± 7 | 85 ± 9 | ||
| ALI-BL | 75 ± 17 | 82 ± 14 | 85 ± 11 | 92 ± 6 | 84 ± 11 | |||
| ALI-End | 86 ± 16# | 94 ± 17# | 71 ± 31 | 77 ± 17# | 80 ± 20 | 0.213 | 0.011 | |
| VE [ml/min] | BL | 334 ± 115 | 328 ± 68 | 348 ± 42 | 353 ± 56 | 339 ± 48 | ||
| ALI-BL | 323 ± 60 | 346 ± 86 | 364 ± 82 | 403 ± 91 | 352 ± 58 | |||
| ALI-End | 318 ± 70 | 411 ± 117 | 320 ± 115 | 396 ± 123 | 330 ± 130 | 0.662 | 0.345 | |
BL baseline measurement on pressure controlled ventilation, ALI-BL measurement on pressure-controlled ventilation after induction of lung injury, ALI-End last measurement after 2–4 h of experimental ventilation mode, PAW peak airway pressure, PTPi peak inspiratory transpulmonary pressure, VT tidal volume, RR respiratory rate, VE minute ventilation, *p < 0.05 vs. other groups #p < 0.05 vs. ALI-BL