Table 2.
Diagnostic examination results of present cases
| Histopath of bullous lesion | DIF | ELISA | Histopath of inflammatory skin lesion that could be DM | PFTs | HLA | |
|---|---|---|---|---|---|---|
|
Case 1 (PV and classic DM) |
Acantholytic dermatosis (Right breast, 4/26/2018) | IgG and C3 deposition intercellularly (left upper back, 4/26/2018) |
Dsg 1: 126.4075 (> 36) Dsg 3: 59.28889 (> 37) (10/05/2018) |
N/A | Order active | N/A |
|
Case 2 (MMP and DM) |
Consistent with pemphigoid (right buccal and gingival mucosa -2004) |
N/A | Vascular ectasia and perivascular inflammation, with rare dyskeratotic cells at the dermoepidermal junction, compatible with connective tissue disorder (Right elbow, 6/12/2018) |
Mild combined restriction and obstruction, with severely reduced diffusing capacity of the lungs for carbon monoxide 8/24/2018 Pulm: combined pulmonary fibrosis and emphysems (has smoking history also). Only fulfilled probable UIP (ILD). Lung biopsy is definitive. |
N/A | |
DIF, direct immunofluorescence; DM, dermatomyositis; Dsg, desmoglein; ELISA, enzyme-linked immunosorbent assay; DIF, HLA, human leukocyte antigen; Ig, immunoglobulin; ILD, interstitial lung disease, MMP, mucous membrane pemphigoid; N/A, not available; PFT, pulmonary function testing; PV, pemphigus vulgaris; UIP, usual interstitial pneumonia