Table 1.

Standard binding free energy gain to construct a buried interface in the direction of backbone axis (ΔG_a°), sidechain axis (ΔG_b°), intra-cell zipper (ΔG_zip°, in the plane perpendicular to the b axis), and hydrogen bond axis (ΔG_c°).

IFQINS Structure	ΔGa°	ΔGb°	ΔGzip°	ΔGc°
designed AP class 5	−9.2 (1)	−6.2 (1)	−16.4 (3)	−29.3 (2)
4R0P crystal class 1	ε/2 = −9.4 (1)	ε + ε′ = −24.8 (2)	−25.3 (2)	−25.3 (2)

For the crystal structure, energies are initially not linear with n_a, n_b, n_c however the linear change per increase in dimension at the limit of large aggregates is shown. Units are kcal/mol/peptide buried by the interface. Parentheses indicate the statistical uncertainty (ESE) in the final digit.