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. 2019 Nov 5;9:16036. doi: 10.1038/s41598-019-52537-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structural analysis of the interaction between the RH1 domain of JIP3 and myo5a-GTD. (a) Superposition of the JIP3-RH1-LZI homology model (orange and green) on the crystal structure of the RH1 domain of RILPL2 (dark grey) bound to myo5a-GTD (shown in cartoon in blue) (PDB code 4KP3). (b) Myo5a-GTD-binding interface on JIP3-RH1domain (left, in orange) and RILPL2-RH1 domain (right, in grey). Residues in interaction with myo5a-GTD are shown in sticks and labeled. (c) Alignment of the RH1 domain between human JIP3 and JIP4 sequences, human RILP, RILPL1 and RILPL2 sequences and the mouse RILPL2 sequence as present in PDB 4KP3_D. This alignment was derived from HHpred results. Regions involved in the interface with myo5a-GTD in 4KP3 are indicated by purple boxes. In red is indicated a possible complementary sequence difference between RILPL2 and JIP3.