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. 2019 Oct 17;24:102025. doi: 10.1016/j.nicl.2019.102025

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4. — Individual and group-level analysis of structural changes in TES patients

Axial T1 weighted MRI of all 11 patients with TES (A) including cavum Septum Pellucidum (CSP) width and length in millimeters (B). Individual atrophy patterns as represented by w-scores of bilateral cortical thickness, subcortical gray matter volume, bilateral hippocampal volume, and ventricular volume compared to normalized control data (based on Potvin et-al (Potvin et al., 2017)) (C). Group-level two sample t-test analysis of atrophy patterns (P_Uncorrected < 0.005 at the voxel level, P_fwe < 0.05 at the cluster level converted to Cohen's d effect size) in the whole TES cohort (n = 11) and the amyloid-negative subgroup only (n = 9) compared with 54 controls. Patient numbers correspond to the same numbers as in Table 1 and in the other figures.

TES – traumatic encephalopathy syndrome; CN – cognitively normal control; CSP – cavum septum pellucidum; GM – gray matter; Lt – left; Rt – right; Vol – volume; Pt – patient; FEW – family wise error corrected.