Table 1.
Patient characteristics.
| Sex | Race1 | Age (decade1) | Education | Impact sport exposure | Years in impact sport | Position played1 | Main presenting symptoms | CDRtotal | CDR SB | MMSE | ApoE status1 | [11C]PIB status | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pt1 | M | 60s | 18 | NFL | 13 (6 as pro.) |
Memory, executive, visuospatial, language, behavior |
1.0 | 7.0 | 4 | Diffuse pos |
|||
| Pt2 | M | 70s | 16 | NFL | 20 (12 as pro.) | Memory, executive, visuospatial, behavior |
1.0 | 4.5 | 24 | Focal pos |
|||
| Pt3 | M | 40s | 16 | College football, Other | 11 | Behavior, memory, language | 0.5 | 4.0 | 22 | Neg | |||
| Pt4 | M | 70s | 16 | NFL | 21 (11 as pro.) |
Memory, executive, headaches | 0.5 | 1.0 | 27 | Neg | |||
| Pt5 | M | 60s | 16 | NFL, Other | 17 (9 as pro.) |
Behavior, motor, memory, blackout episodes | 0.5 | 3.5 | 28 | Neg | |||
| Pt6 | M | 60s | 16 | Baseball, College football | 8 | Memory, executive, language, visuospatial, behavior | 0.5 | 2.0 | 27 | Neg | |||
| Pt7 | M | 40s | 18 | Rugby, HS football | 9 | Memory, post-traumatic epilepsy | 0.5 | 0.5 | 29 | Neg | |||
| Pt8 | M | 30s | 16 | NFL, wrestling | 23 (3 as pro.) |
Mood, sleep | 0.5 | 2.5 | 27 | Neg | |||
| Pt9 | M | 60s | 16 | NFL | 18 (8 as pro) |
Executive, minimal memory | 0.5 | 2.0 | 27 | Neg | |||
| Pt10 | M | 60s | 14 | Other | 11 | Memory, executive | 0.5 | 3.5 | 25 | Neg | |||
| Pt11 | M | 50s | 16 | NFL | 18 (2 as pro.) |
Executive, memory, visuospatial, mood | 1.0 | 4.5 | 27 | Neg | |||
| All TES Patients, n = 11 | 100% M |
82% - W 9% - B 9% - Mixed |
60 s (30s-70 s) |
16 (14–18) |
7 retired NFL 4 other contact sports |
– | Detailed description in the legend2 | – |
CDR 1: 3 CDR 0.5: 8 |
3 (0.5–7) |
24 (4–29) |
E3/3: 63.6% E2/4: 18.2% E3/4: 9.1% E2/2: 9.1% |
2 Pos 9 Neg |
- Specific ages, race, positions played and individual ApoE genotyping are not given to maintain anonymity.
– Number of individuals in each position: defensive line: 2; linebacker: 3; defensive back: 2; special teams: 4; offensive lineman: 2; quarterback: 2; running back: 1; wide receiver: 1; no record: 1; no football exposure: 1; Some individuals played more than one position.
Abbreviations: AD – Alzheimer's disease; TES – Traumatic Encephalopathy Syndrome; CDR – Clinical Dementia Rating; SB – Sum of Boxes; Pt – Patient; Pro. - Professional; NFL – National Football League; Pos – Positive; Neg – Negative; HS – High school; FTP = flortaucipir; FDG – fludeoxyglucose; M – male; W – White, B – Black/African-American;
Continuous variables are presented as mean (range).