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. 2019 Oct 30;12:260. doi: 10.3389/fnmol.2019.00260

Figure 3.

Figure 3

MiR-137 cKO mice exhibit alterations in synaptic plasticity. (A) SC-CA1 synapses in the miR-137 cKO hippocampus showed suppressed long-term potentiation (LTP) induced by high-frequency stimulation (HFS), compared to WT littermate controls (n = 5 slices from four mice for WT and 6, 4 for cKO, ****p < 0.0001, two way ANOVA). Arrows indicate application of HFS. (B) LTP magnitude presented as mean fEPSP slope of the last 5 min (55–60 min) of recording. (C) Traces showing mEPSCs recorded from primary cultured hippocampal neurons from WT (Anacker and Hen, 2017) and miR-137 cKO (bottom) mice, scale bar: 10 pA, 1 s. (D,E) Cumulative probability, and summarized mean values (F,G) of mEPSCs amplitude (D,F) and frequency (E,G) recorded from primary cultured hippocampal neurons from miR-137 cKO mice and their WT littermates (n = 7, *p < 0.05, student’s t-test).