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. 2019 Oct 30;12:260. doi: 10.3389/fnmol.2019.00260

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Copyright © 2019 Yan, Sun, Wang, Liu, Mi, Liu, Wang, He, Du, Liu and Teng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-137 cKO mice exhibit alterations in synaptic plasticity. (A) SC-CA1 synapses in the miR-137 cKO hippocampus showed suppressed long-term potentiation (LTP) induced by high-frequency stimulation (HFS), compared to WT littermate controls (n = 5 slices from four mice for WT and 6, 4 for cKO, ****p < 0.0001, two way ANOVA). Arrows indicate application of HFS. (B) LTP magnitude presented as mean fEPSP slope of the last 5 min (55–60 min) of recording. (C) Traces showing mEPSCs recorded from primary cultured hippocampal neurons from WT (Anacker and Hen, 2017) and miR-137 cKO (bottom) mice, scale bar: 10 pA, 1 s. (D,E) Cumulative probability, and summarized mean values (F,G) of mEPSCs amplitude (D,F) and frequency (E,G) recorded from primary cultured hippocampal neurons from miR-137 cKO mice and their WT littermates (n = 7, *p < 0.05, student’s t-test).