Skip to main content
. 2019 Sep 24;14:7593–7607. doi: 10.2147/IJN.S220410

Table 4(A).

Synthesis and characterization of various types of chitosan-based nanoparticles in vitro and in vivo environments, reported in different studies

Reference
Properties
48 5 27 24 7 Present study
Name NQC-AmpB HePC-AmB-CNLCs Cs-PF-AmB-M Chitosan-coated AmB-loaded SLNs MTC AmB AK
Nanoparticle size (nm) 135 148 102
Nanodrugs size (nm) 155 150 156 166 362 112
Synthesis method Ionic gelation Emulsification and homogenization Ionic gelation Emulsification and solvent evaporation Ionic gelation Phase separation
Drug loading efficiency (%) and methods used for confirmation 81%; DLS, SEM, TEM 80%; DLS, TEM 63%; DLS 82%; SEM, DLS 73%; FTIR, SEM 90%; DLS, SEM, TEM, AFM, HNMR, FTIR
Pattern of drug release Controlled release Controlled release Controlled release Biphasic Controlled release Controlled release
Cellular uptake (%) 32% 55% 22% 34% 45% 98.6%
In vitro viability (%) (MTT) 50% at 9 µg/mL 58% at 10 µg/mL 72% at 20 µg/mL 49% at 20 µg/mL 34% at 57 µg/mL 100% at 20 µg/mL
Promastigote killing (%) 50% at 1 µg/mL 82% at 20 µg/mL
Amastigote inhibition (%) 61% 68% 50% 50% 61% 78%
Leishmania species Amazonensis Donovani Donovani Donovani Donovani Major